Incidence of B-cell Leukemia Among Kurdish People in Erbil City

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Athors:Tanya Salam Salih,
Biology Department – College of Science, Cihan University – Erbil

Author: Suhaila N.R. Darogha
Biology Department – College of Education, University of Salahaddin

DOI: http://dx.doi.org/10.24086/cuesj.si.2017.n2a18

Abstract

This study was carried out in Nanakaly hospital for blood disease in Erbil city, during November 2013 to November 2014. The study was designed to investigate the prevalence of different types of leukemia in Erbil Province in Kurdistan Region.138 cases were studied of different types of leukemia diagnosed by peripheral blood count, peripheral blood smear examination, bone marrow aspiration and immune-phenotyping by flow cytometery. The results showed that from 138 patients, 68 (49.28%) patients suffered with B-cell lineage disorders, while 44(31.88%) patients afflicted with myloid lineage disorders fllowed by 13(9.42%) patients affected with T-cell lineage disorders. The results showed that from 68 patients, 38 (55.88%) affected with acute lymphocytic leukemia (ALL) followed by 26 (38.24%) chronic lymphocytic leukemia (CLL), 3 (4.41%) and 1 (1.47%) of patients represent hairy cell leukemia (HCL) and Burkett’s lymphoma respectively. The result indicated obvious relation between age and B-cell leukemia, BALL was most frequent in children and B-CLL related to older age.

Keywords: Epidemiology of leukemia; B-cell leukemia; risk factor, Erbil

References

• Hejmadi, “Introduction of cancer biology,” 1st Edn., Ventus Publishing APS, 2010.
• Bray , A. Jemal and N. Grey , “Global cancer transitions according to the Human Development Index (2008-2030): a population-based study,” Lancet Oncol,Vol. 13, 2012, pp. 790-801.
• Jemal, F. Bray and M.M. Center, “Global cancer statistics,” Ca Cancer J Clin, Vol. 61,2011, pp. 69-90.
• J. Bain, D.M. Clark, and B.S. Wilkins, “Bone marrow pathology,” 4th Edn., Wiley-Blackwell: A John Wiley and Sons, Ltd., Publication, 2010.
• Chaudhari, J.S. Desai, A. Adam, and P. Mishra, Jak/stat as a novel target for treatment of leukemia. Int. J. Pharm. Pharmaceut. Sci., col. 6, no. 1, 2014, pp. 1-7.
• Ministry of Health results on Iraqi Registry, “Iraqi Cancer Boar,” Baghdad-Iraqi, 2008.
• Peto, “Cancer epidemiology in the last century and the next decade,” Nature, Vol. 411, No. 6835, 2001, pp. 390-595.
• C. Thachuk, and J.V. Hieschmann, “Leukemia. In Wintrobes atlas of clinical hematology,” 1^st edition Lippincott Williams, 2009, pp. 134-148.
• Cassidy, D. Bissett, A.J. Roy, and O.B.E. Spence, “Acute leukemia. In oxford university press,” 2010, pp. 528-539.
• Lin, S. Hao, L.J. Medeiros, E.H. Estey, S.A. Pierce, X. Wang, “Expression of CD2 in acute promyelocytic leukemia correlates with short form of PML-RARN transcripts and poorer prognosis,” Amer. J. Clin. Patho.,Vol. 121, No. 3, 2004, pp. 402-407.
• J. Hamblin, “Prognostic Markers in Chronic Lymphocytic Leukaemia,” Best Pract. Res. Clin. Haematol., Vol. 20, No. 3, 2007, pp. 455-468.
• Oscier, D.; Fegan, C.; Hillmen, P.; Illidge, T.; Johnson, S.; Maguire, P. (2004). “Guidelines on the diagnosis and management of chronic lymphocytic leukaemia,” Br. J. haematol., Vol. 125, No. 3, 294-317.
• Graux, “Biology of acute lymphoblastic leukemia (ALL): clinical and therapeutic relevance,” Transfus. Apher. Sci., Vol. 44, 2011, pp. 183-189.
• Siegel, J. Ma, Z. Zou, and A. Jemal, “Cancer statistics,” Cancer J.Clin., Vol. 64, No. 1, 2014, pp. 9-29.
• Gusbi, A. Elouzi, E. BenOmran, M. Arhima, E.B. Zekre, and E. BenAyad, “Risk factors of childhood leukemia at Tripoli medical center in Libya,” Amer. J. Pharm. Pharmacol., Vol. 1, No. 2, 2014, pp. 17-22.
• Al-Ghazaly, W. Al-Dubai, M. Abdullah, A. Al-Mahagri, and L. Al- Gharasi, “A ten year descriptive study of adult leukaemia at Al-Jomhori teaching hospital in Sana’a, Yemen,” Yemen J. Med. Sci., Vol. 8, 2014, pp. 6-12.
• A. Hamasaeed, “Assessment of some microbiological and immunological factors in leukemia patients,” Ph.D Thesis, University of Mosul, College of Sci., Iraq, 2014.
• Rodriguez-Abreu, A. Bordoni, and E. Zucca, “Epidemiology of hematological malignancies,” Ann. Oncol., Vol. 18, 2007, pp. 3-8.
• P. Meijerink, M.L. den Boer, and R. Pieters, “New genetic abnormalities and treatment response in acute lymphoblastic leukemia. Hematology, Vol. 46, No. 1, 2009, pp. 16-23.
• Ibagy, D.B. Silva, J. Seiben, A.P. Winneshoffer, T.E. Costa, J.S. Dacoregio, I. Costa, and D. Faraco, “Acute lymphoblastic leukemia in infants: 20 years of experience,” J.Pedia., Vol. 89, No. 1, 2013, pp. 64-69.
• Wu, L. Fischer, N. Gökbuget, S. Schwartz, T. Burmeister, M. Notter, D. Hoelzer, H. Fuchs, I.W. Blau, W.K. Hofmann, and E. Thiel, “Expression of interleukin 15 in primary adult acute lymphoblastic leukemia,” Cancer, Vol. 116, No. 2, 2010, pp. 387-392.
• A. Alrudainy, J.G. Hassan, H.M. Salih, M.K. Abbas, and A.A. Majeed, Time trends and geographical distribution of childhood leukaemia in basrah, iraq, from 2004 to 2009. Sultan Qaboos University Med. J., Vol. 11, No. 2, 2011, pp. 215-220.
• Dyer, “WHO suppressed evidence on effects of depleted uranium, expert says,” Br Med J, Vol. 333, No. 7576, 2006, pp. 990.
• A. Bullman, C.M. Mahan, H.K. Kang, and W.F. Page, “Mortality in US army gulf war veterans exposed to 1991 Khamisiyah chemical munitions destruction,” Am. J. Public. Health., Vol. 95, No. 8, 2005, pp. 1382-1388
• Rathee, M. Vashist, A. Kumar, and S. Singh, “Incidence of acute and chronic forms of leukemia in Haryana,” Inter. J. Pharm. Pharmaceu. Sci., Vol. 6, No. 2, 2014, pp. 323-325.
• S. Arora, T.O.B. Eden, and G. Kapoor, Epidemiology of childhood cancer in India. Indian J. Cancer, Vol. 46, No. 4, 2009, 2009, pp. 264-273
• K. Kenealy, C.B. Christenson, and C.B. Williams, (2008). Current therapies for chronic myeloid leukemia,” Int. J. Phar. Prac., Vol. 21, No. , 2008, pp. 116-125.
• T. Dorak, “Childhood cancer epidemiology,” http://www.dorak.info/epi/ccepi.html, 2013.
• A. Al-Barazanchi, A.K. Al-Sani, and N.F. Naema, “Hematological and cytomorphological study of Acute Lymphoblastic Leukemia (ALL),” Bahrain Med. Bull., Vol. 27, No. 4, 2005, pp. 1-4.
• B. Jmili, A. Ben Abdel Aziz, M. Nagara, T. Mahjoub, H. Ghannem, and M. Kortas, Cytological features of acute leukaemia in the central region of Tunisia,” East. Mediter. Health J., Vol. 10, 2004, pp. 4-5.
• Kumar, R. Rathee, M. Vashist, N. Kamal, S. Singh, and S. Gupta, “Acute Lymphocytic Leukemia: An epidemiological and hematological study from Haryana,” Biosci. Biotech. Res. Asia., Vol. 9, No. 2, 2012, pp. 813-817.
• K. Mohammed, N. Abed, S.J. Al-khalidy, and K.J. Al-rubaiy, “Study on Acute Leukemia in Iraqi population,” Iraqi J. Sci., Vol. 46, No. 1, 2005, pp. 86-89.