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Effect of Polymorphism Ser447stop Lipoprotein Lipase Gene on the Concentration of Testosterone in Male is Infertile in the City of Samarra

Authors: Omar Rahem Khalaf Al-Obaidy
Dept. of biology, College of education, University of Samarra,

DOI: http://dx.doi.org/10.24086/cuesj.si.2017.n2a3

Abstract

Infertility of healthy problems is considered important that cause damage to psychological, economic and family couple infertile. Disease occurs because of many genetic factors and physiological. It has been observed that the 30% of infertility male caused by mutations which is still accurate diagnosis of these mutations incomplete. As the most important characteristic of these mutations, the defect is in the fertility of individuals, although that individual show natural mature but linked to infertility. Therefor the study aimed is to identify the effect of polymorphism Ser447stop for lipoprotein lipase (LPL) gene on the concentration of testosterone and produce sperm in the male infertile. As the study including 70 male infertile and 40 male healthy. It has been selected from hospital of Samarra, the period from 8/3/2016 to 3/7/2016. The results showed high concentration of LPL enzyme in the males infertile ,as amounted to 41,76 U/L compared with healthy which amounted to 32,18 U/L. Either concentration of testosterone decreased concentration of the infertile, as amounted to 2.14 ng/ml, while the healthy 4.69 ng/ml. As for genotype frequency of polymorphism Ser447stop, It has been observed the absence of the difference in the genotype frequency between the community infertile and healthy. While found high significant in allele frequency of X447 in patients, compared with healthy. It also been associated with genotype X447X447 decrease in the indicators of seminal fluid as well as decrease in testosterone, with increase in the LPL enzyme for individual’s carriers with him. Suggesting the role of polymorphism for LPL gene in the disease infertile progression through the influence on the activity and amount of the enzyme product.

Key words: Polymorphism Ser447stop, Lipoprotein lipase (LPL) gene, Testosterone, Infertile

 

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