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Evaluation of HbA1c and Oxidation Status in Diabetic Patients (Type 2) in Erbil Governorate

Author: Sarwar Nawzad Jahfar
Department of Biology, College of Education, University of Salahaddin

Author: Nadir Mustafa Qadir Nanakali
Department of Biology, College of Education, University of Salahaddin, cihan Univerity-Erbil

DOI: http://dx.doi.org/10.24086/cuesj.si.2017.n2a4

Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in either insulin secretion or insulin action, or both. The chronic hyperglycemia in diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. This study was carried out from the period of December 2010 to June 2011.  Fasting blood samples were obtained from one hundred fifty-two diabetic patients (59 males and 93 females) of type 2 and 50 apparently clinically healthy individuals were selected as a normal group (29 males and 21 females).

The results showed that the mean HbA1c percentage were significantly higher in diabetic patients (9.18%) than normal group percentage (5.57%). Results showed that mean serum Superoxide dismutase activity in diabetic (0.202) IU/L was significantly higher than normal (0.123) IU/L groups. While mean serum glutathione levels (37.726) µmol/L was significantly lower in diabetic patients, than in normal group (42.931) µmol/L. beyond that mean vitamin E (9.9) µmol/L was significantly lower in diabetic patients, than normal group (15.6) µmol/L. The results revealed high level were of serum MDA (1.60) µmol/L in diabetic patients compared to in normal group (1.27) µmol/L. we concluded that diabetes mellitus affects negatively the level of lipid profile and antioxidants vitamin E and Glutathione while lead to increased Malondialdehyde, patients of diabetes mellitus have high HbA1c Values.

Keywords: HbA1c, Antioxidants, Diabetes.

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