Antibacterial Activity of Zinc Oxide Nanoparticles Against Staphylococcus Aureus and Pseudomonas Aeruginosa Isolated from Burn Wound Infections

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Author: Emad Jalel Ibrahem
Dept. of Medical Microbiology Sulaimani Directorate of Health, Ministry of Health Kurdistan
Authors: Youssef Shakuri Yasin,  Omar Khalil Jasim
The State company for Drugs and Industry and Medical Appliances, Samarra, Ministry of  Industry and Mineral

DOI: http://dx.doi.org/10.24086/cuesj.si.2017.n2a24

Abstract

This study was carried out to determine the antibacterial activity of Zinc oxide Nanoparticles (ZnO NPs) against isolated bacterial pathogens  from burn infections in wound. The burn wound were collected from 72 patients, 64(88.9%) were positive cases (12 males and 52female) and 8 (11.1%) were no growth.The majority of the gram negative bacteria isolated Pseudomonas aeruginosa 35(58.3 %) was found, but Staphylococcus aureus 7(10%). Also the results of antimicrobial susceptibility test showed that the highest antibacterial resistance against  Ampicillin 100%, Rifampicin 100%, Cefotaxime 90.6%, Tetracycline 78.1% , Nalidixic acid 68.7 %, Trimethoprim 57.9%, Nitrofurantoin 54.7 %. Furthermore, the results showed inhibit zone of bacterial growth was 25, and 28 mm in diameter for Staphylococcus aureus and Pseudomonas aeruginosa respectively.

Keywords: Zinc Oxide nanoparticles, antibiotic resistance., Candida albicans, SEM, antibacterial study, reactive oxygen species.

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